SC - 1151 | Biomaterials for Cell Delivery: Vehicles in Regenerative Medicine (Gene and Cell Therapy)

Biomaterials for Cell Delivery: Vehicles in Regenerative Medicine (Gene and Cell Therapy) 1st Edition by Aaron S. Goldstein (Editor)

The purpose of this book is to summarize key strategies and recent accomplishments in the area of developing cell/biomaterial constructs for regenerative medicine.

The first section is a review of the state-of-the-art of biomaterial carriers and is divided into synthetic and natural materials. A subset of the latter are decellularized organs which retain the structure and some of the biological activities of the target organ. The bulk of the book is devoted to unique problems associated with key tissue and organ targets.

Key selling features:

Describes developing cell/biomaterial constructs for regenerative medicine
Reviews state-of-the-art of biomaterial carriers
Summarizes the unique problems associated with key tissue and organ targets
Discusses issues associated with clinical translation including quality control, manufacturing practices, nondestructive imaging, and animal models

2019 | ISBN-10: 1498743161 | ID: SC - 1151

Read More ...

281 - Molecular Immunotoxicology

Molecular Immunotoxicology by Emanuela Corsini (Editor), Henk Van Loveren (Editor)

The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system.

Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered.

Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models.

Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.

2014 | ISBN: 3527335196 |  ID - 281

Read More ...

289 - Protein Tyrosine Phosphatases in Cancer

Protein Tyrosine Phosphatases in Cancer by Benjamin G. Neel (Editor), Nicholas K. Tonks (Editor)

This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology.

The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts.
Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.

2016 | ISBN: 1493936476, 1493981064 |  ID - 289

Read More ...

330 - Integrated Biomaterials for Biomedical Technology

Integrated Biomaterials for Biomedical Technology (Biomedical Science, Engineering, and Technology Book 6) by Murugan Ramalingam (Editor), Ashutosh Tiwari (Editor), Seeram Ramakrishna (Editor), Hisatoshi Kobayashi (Editor)

This cutting edge book provides all the important aspects dealing with the basic science involved in materials in biomedical technology, especially structure and properties, techniques and technological innovations in material processing and characterizations, as well as the applications.

The volume consists of 12 capters written by acknowledged experts of the biomaterials field and covers a wide range of topics and applications.

2012 | ISBN: 1118423852 |  ID - 330

Read More ...

405 - JIMD Reports, Volume 45

JIMD Reports, Volume 45 by Eva Morava (Editor), Matthias Baumgartner (Editor), Marc Patterson (Editor), Shamima Rahman (Editor), Johannes Zschocke (Editor), Verena Peters (Editor)

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders.

Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

2019 | ISBN-10: 3662586460 | ID - 405

Read More ...

368 - Autoantibodies: Methods and Protocols

Autoantibodies: Methods and Protocols (Methods in Molecular Biology) by Gunnar Houen (Editor)

This volume covers methods for determination of autoantibodies in rheumatic connective tissue diseases and organ-specific diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Autoantibodies: Methods and Protocols aims to be helpful for all persons working with research and development of autoimmune laboratory diagnostics and for clinicians using autoantibody tests in daily work with patients.

2018 | ISBN: 1493989480 | ID - 368

Read More ...

372 - Co-Immunoprecipitation Methods for Brain Tissue

Co-Immunoprecipitation Methods for Brain Tissue (Neuromethods) by Yuji Odagaki (Editor), Dasiel O. Borroto-Escuela (Editor)

This volume covers various aspects of co-immunoprecipitation (co-IP) methods and its relevant use in studying protein-protein interactions (PPIs) in health and diseases of the Central Nervous System.

The chapters in this book discuss topics such as using co-IP to detect G protein-coupled receptors (GPCR), receptor tyrosine kinases (RTK) and ion channels heteroreceptor complexes in brain tissue; the histoblot technique; interaction strength between synaptic proteins using COS-7; and co-IP analysis of the protein-protein interactions in the neurons of Polymita. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and thorough, Co-Immunoprecipitation Methods for Brain Tissue is a valuable resource for any researcher interesting in learning more about this developing field.

2018 | ISBN: 1493989847 | ID - 372

Read More ...

SC - 456 | Finite Mixture of Skewed Distributions

Finite Mixture of Skewed Distributions by Víctor Hugo Lachos Dávila (Author), Celso Rômulo Barbosa Cabral (Contributor), Camila Borelli Zeller (Contributor)

This book presents recent resuls in finite mixtures of skewed distributions to prepare readers to undertake mixture models using scale mixtures of skew normal distributions (SMSN).

For this purpose, the authors consider maximum likelihood estimatio for univariate and multivariate finite mixtures where components are members of the flexible class of SMSN distributions.

This subclass includes the entire family of normal independent distributions, also known as scale mixtures of normal distributions (SMN), as well as the skew-normal and skewed versions of some other classical symmetric distributions: the skew-t (ST), the skew-slash (SSL) and the skew-contaminated normal (SCN), for example. These distributions have heavier tails than the typical normal one, and thus they seem to be a reasonable choice for robust inference. The proposed EM-type algorithm and methods are implemented in the R package mixsmsn, highlighting the applicability of the techniques presented in the book.

This work is a useful reference guide for researchers analyzing heterogeneous data, as well as a textbook for a graduate-level course in mixture models. The tools presented in the book make complex techniques accessible to applied researchers without the advanced mathematical background and will have broad applications in fields like medicine, biology, engineering, economic, geology and chemistry.

2018 | ISBN: 3319980289 | ID: SC - 456

Read More ...

SC - 469 | Immobilized β-Galactosidase-Mediated Conversion of Lactose

Immobilized β-Galactosidase-Mediated Conversion of Lactose: Process, Kinetics and Modeling Studies by Fadzil Noor Gonawan (Author)

This book describes the reaction rate profiles of the ss-galactosidase-catalyzed conversion of lactose on the inner surface of a hollow fiber membrane, which is employed as an enzymatic reactor system. The reaction rate profiles were obtained by solving the mass transfer and kinetics of reaction in a 2-dimensional model of the system.

The primary challenge of this research was to develop the kinetic model of the reaction to describe the kinetic behavior as the reaction occurred on the membrane surface. Despite the difficulties, the proposed model can reliably replicate the actual process, as validation procedures have confirmed. The reaction rates obtained analyze the performance of the immobilized enzyme on the membrane surface. Previously, an increase in performance of 'ss-galactosidase-catalyzed conversion of lactose assisted by ultrafiltration was suggested due to inhibitor removal. However, as the analysis presented here shows, the concentration profile of the substrate on the membrane surface also affects the reaction performance.

2019 | ISBN-10: 9811334676 | ID: SC - 469

Read More ...

SC - 473 | Protein Dimerization and Oligomerization in Biology

Protein Dimerization and Oligomerization in Biology (Advances in Experimental Medicine and Biology) by Jacqueline M. Matthews (Editor)

This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.

2012 | ISBN: 1461432286 | ID: SC - 473

Read More ...

SC - 509 | Advances in Membrane Proteins: Part I

Advances in Membrane Proteins: Part I: Mass Processing and Transportation by Yu Cao (Editor)

The book summarizes advances in biochemical and biophysical property of membrane proteins as well as their applications in biomedicine. It is organised into 2 themed parts. This part focuses on mass processing and transportation and provides deep and comprehensive information on specific groups of membrane proteins including channels and transporters, nuclear and cytoplasmic membrane proteins, and membrane embedded enzymes.

Their structures, functions, related diseases as well as their roles in drug discovery are fully discussed. Interesting topics cover fundamental concepts, latest progress and critical puzzles yet to be solved. This work will appeal to a wide readership within the membrane structural and functional biology field. Junior scientists could use it to fast track into the field. Advanced scientists will find it helpful to gain a broader view of the field beyond their area of specialization.

2018 | ISBN: 9811305315 | ID: SC - 509

Read More ...

SC - 536 | Antibacterials: Volume II

Antibacterials: Volume II (Topics in Medicinal Chemistry) by Jed F. Fisher (Editor), Shahriar Mobashery (Editor), Marvin J. Miller (Editor)

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs.

Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

2018 | ISBN: 3319708384 | ID: SC - 536

Read More ...

SC - 537 | JIMD Reports, Volume 17

JIMD Reports, Volume 17 by Johannes Zschocke (Editor), K. Michael Gibson (Editor), Garry Brown (Editor), Eva Morava (Editor), Verena Peters (Editor)

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

2014 | ISBN: 3662445778 | ID: SC - 537

Read More ...

SC - 578 | Medicinal and Aromatic Plants of South America

Medicinal and Aromatic Plants of South America: Brazil (Medicinal and Aromatic Plants of the World Book 5) by Ulysses Paulino Albuquerque (Editor), Umesh Patil (Editor), Ákos Máthé (Editor)

This volume in the series deals with the major Medicinal and Aromatic Plants (MAPs) of South America, providing information on major aspects of this specific group of plants on that continent (botany, traditional usage, chemistry, production/collection practices, trade and utilization).

Brazil, in particular, offers an immense amount of biodiversity, including plants with great pharmacological interest and ethno-medicinal importance. Contributions are from internationally recognized professionals, specialists of the Medicinal and Aromatic Plant domain and have been invited mostly from the members of the International Society for Horticultural Science and International Council for Medicinal and Aromatic Plants.

2018 | ISBN-10: 9402415505 | ID: SC - 578

Read More ...

SC - 585 | The Neural Basis of Human Belief Systems

The Neural Basis of Human Belief Systems (Contemporary Topics in Cognitive Neuroscience) by Frank Krueger (Editor), Jordan Grafman (Editor)

Is the everyday understanding of belief susceptible to scientific investigation? Belief is one of the most commonly used, yet unexplained terms in neuro-science. Beliefs can be seen as forms of mental representations and belief as one of the building blocks of our conscious thoughts.

This book provides an interdisciplinary overview of what we currently know about the neural basis of human belief systems, and how different belief systems are implemented in the human brain.

The chapters in this volume explain how the neural correlates of beliefs mediate a range of explicit and implicit behaviors ranging from moral decision making to the practice of religion. Drawing inferences from philosophy, psychology, psychiatry, religion, and cognitive neuroscience, the book has important implications for understanding how different belief systems are implemented in the human brain, and outlines the directions which research on the cognitive neuroscience of beliefs should take in the future. The Neural Basis of Human Belief Systems will be of great interest to researchers in the fields of psychology, philosophy, psychiatry, and cognitive neuroscience.

2013 | ISBN: 1841698814 | ID: SC - 585

Read More ...

SC - 588 | Our Senses: An Immersive Experience

 Our Senses: An Immersive Experience by Rob DeSalle, Patricia J. Wynne
 
A lively and unconventional exploration of our senses, how they work, what is revealed when they don't, and how they connect us to the world.
Over the past decade neuroscience has uncovered a wealth of new information about our senses and how they serve as our gateway to the world.

This splendidly accessible book explores the most intriguing findings of this research. With infectious enthusiasm, Rob DeSalle illuminates not only how we see, hear, smell, touch, taste, maintain balance, feel pain, and rely on other less familiar senses, but also how these senses shape our perception of the world aesthetically, artistically, and musically.

DeSalle first examines the question of how perception and consciousness are formed in the brain, setting human senses in an evolutionary context. He then investigates such varied themes as supersenses and diminished senses, synesthesia and other cross-sensory phenomena, hemispheric specialization, diseases, anomalies induced by brain injuries, and hallucinations. Focusing on what is revealed about our senses through the extraordinary, he provides unparalleled insights into the unique wonders of the human brain.

2018 | ISBN: 0300230192 | ID: SC - 588

Read More ...

SC - 615 | Hybridization, Diagnostic and Prognostic of PEM Fuel Cells

Hybridization, Diagnostic and Prognostic of PEM Fuel Cells: Durability and Reliability by Samir Jemei (Author)

Hydrogen is the most abundant element in the universe. It has a place in the energy mix of the future, especially regarding fuel cells (FCs). This book is an investigation into FCs. Prominence is given to the subject of PEMFCs (proton exchange membrane fuel cells) as they offer interesting perspectives on transport and stationary applications.

This being said, a number of technological and scientific obstacles remain to be overcome before an industrial level of development can be reached.

ISBN: 1786301679 | 2018 | ID: SC - 615

Read More ...

SC - 654 | Computational Cell Biology

Computational Cell Biology: Methods and Protocols (Methods in Molecular Biology) by Louise von Stechow (Editor), Alberto Santos Delgado (Editor)

This volume details computational techniques for analyses of a wide range of biological contexts, providing an overview of the most up-to-date techniques used in the field.

Chapters guide the reader through available data resources and analysis methods and easy-to-follow protocols that allow the researcher to apply various computational tools to an array of different data types. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory and computational protocols, and tips on troubleshooting and avoiding known pitfalls.

2018 | ISBN: 1493986171 | ID: SC - 654

Read More ...

SC - 683 | X-Ray Diffraction of Ions in Aqueous Solutions

X-Ray Diffraction of Ions in Aqueous Solutions: Hydration and Complex Formation by Magini Magini (Author)

The idea of writing a book about the structural investigations of ionic solutions by X-ray diffraction (XRD) wandered in the authors' minds for a long time. In fact, while research activities in this field have largely increased in the last 15 years, utilizing well-established diffractometric techniques, a complete review of the up to date results has been never attempted.

More recently, the authors became aware, as it is better explained in the Foreword, of the presence of some confusion in the literature whenever results on the structure of solutions were mentioned. For these reasons, and thanks to the interest of CRC Press the authors came to the decision of examining all the material presently available, with the aim to present to the interested reader an exhaustive and reasoned selection of it. In this perspective, the authors felt that their work had to include, beside the rational classification of the results, also a comprehensive treatment of the theoretical principles of the X-ray diffraction approach as used when dealing with nonordered systems, as well as a detailed description of experimental and interpretative methods. Therefore, this book should be useful not only to scholars interested in results, but also to students approaching the field of nonordered systems. To them, the authors hope to convey the right feeling about the reliability of XRD information.

It is now widely accepted by chemists, biochemists, and physicists that ion-water inter actions are responsible for the routes of many chemical and biochemical processes; it has also become evident, from the numerous studies on ionic hydration, that any further progress in this field is strongly dependent on a satisfactory structural description of solutions. To this end, the general methods used in the study of any liquid or amorphous system can be applied.

Year: 2018 | ID: SC - 683

Read More ...

SC - 702 | Animal Personality: The Science Behind Individual Variation

Animal Personality: The Science Behind Individual Variation by Jill R.D. MacKay

From ‘scaredy cats’ to ‘moody cows,’ we often give animals personality when we talk about them, but does this have any basis in scientific fact? Only recently has science confirmed that animals have distinct individual personalities, shown through behavioural research.

Animal Personality introduces the fundamentals of personality science and research, describing the history of behavioural testing, and then drills into scientific measurement, recording, and statistical analysis of individual personalities in animals. The author shows how the implications of animals having personalities affects how we treat and care for pets, farm animals, and wildlife. Interesting questions are posed, such as what is the evolutionary reason for traits like fearfulness, aggression and sociability? And it questions long held beliefs about animal traits such as dominance theory.

Animal Personality provides a fascinating and informed insight into the science of personality and its application to non-human animals. Ethologists and animal owners will find this an illuminating and thought-provoking resource. [Subject: Veterinary Studies, Ethology, Animal Welfare]

Year: 2018 | ID: SC - 702

Read More ...